Khlong Om Non (Thai: คลองอ้อมนนท์, pronounced [kʰlɔ̄ːŋ ʔɔ̂ːm nōn]) is a khlong (canal) in Nonthaburi Province, a part of Greater Bangkok.

The khlong was canalized in accordance with the orders of King Prasat Thong in the middle of the late Ayutthaya period to create a shortcut route of the Chao Phraya River. Its history is similar to Khlong Bangkok Yai and Khlong Bangkok Noi in Bangkok, in that the shortcut route's completion caused the original course of the Chao Phraya River to be reduced to only a khlong.