The Zambaccian Museum in Bucharest, Romania is a museum in the former home of Krikor Zambaccian (1889 –1962), a businessman and art collector. The museum was founded in the Dorobanți neighbourhood in 1947, closed by the Ceauşescu regime in 1977, and re-opened in 1992. It is now a branch of The National Museum of Art of Romania. Its collection includes works by Romanian artists—including a masterful portrait of Zambaccian himself by Corneliu Baba—and works by several French impressionists. It is located not far from Piaţa Dorobanţilor on a street now renamed after Zambaccian.

At the time the museum was founded, the act of donation stated that it must be housed in Zambaccian's former home. However, after the 1977 Bucharest earthquake (which did no detectable damage to the museum building), the Romanian government created the Museum of Art Collections, consolidating many of the city's smaller museums (and a good number of expropriated private collections). The Zambaccian collection still resided at the Museum of Art Collections at the time of the Romanian Revolution of 1989; it was returned to its historic location in 1992.