St Andrew's Square is a public square in the city of Glasgow, Scotland and lies to the south east corner of Glasgow Cross, close to Glasgow Green. The square is noted for its immense 18th-century classical church, St Andrew's in the Square, from which the square takes its name. The church was completed in 1758, to the designs of architect Allan Dreghorn and master mason Mungo Naismith and is among the finest of its type anywhere in Britain. The interior has lavish 18th century rococo plasterwork. The building is Category A listed. It is one of six squares in the city centre.

The church standing amidst fields on the banks of the Molendinar Burn, was later enclosed by a square, encouraged by the town council who sold the ground to builder developer William Hamilton of Glassford, Lanarkshire, building between 1786 and the early 1790s. He was also the architect of the Tontine in the Trongate. The square became a fashionable residence for some of Glasgow's wealthiest merchants. "Here and in Virginia Street were domiciled the best and wealthiest in the city." The Royal Bank of Scotland opened here in the 18c with David Dale in charge of the agency. Sulman's panoramic Bird's Eye View of Glasgow published in 1864 shows the Square conveniently close to the mercantile centre of Glasgow Cross and the University of Glasgow in High Street.