Greenville (; locally ) is a city in and the seat of Greenville County, South Carolina, United States. With a population of 70,720 at the 2020 census, it is the sixth-largest city in the state. Greenville is located approximately halfway between Atlanta, Georgia, and Charlotte, North Carolina, along Interstate 85. Its metropolitan area also includes Interstates 185 and 385. Greenville is the anchor city of the Upstate, a combined statistical area with a population of 1,487,610 at the 2020 census. Greenville was the fourth fastest-growing city in the United States between 2015 and 2016, according to the U.S. Census Bureau.

Greenville is the center of the Upstate region of South Carolina, creating one of the largest urban centers in the Deep South. Numerous large companies are located within the city, such as Michelin, Prisma Health, Bon Secours, and Duke Energy. Greenville County Schools is another large employer and is the largest school district in South Carolina. Having seen rapid development over the past two decades, Greenville has also received many accolades and awards. Some of these include "The South’s Most 'Tasteful' Small Towns" from Forbes in 2020, "15 of the Most Underrated Travel Destinations of the Year, So Far" from Insider in 2019, "Best Places to Live" from Money in 2019, and "Best Place to Live in the USA #22" from U.S. News & World Report in 2019. The city continues to expand rapidly into the 2020s as is evident from rapid population, economic, and developmental growth.

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