Gulfport is a closed Amtrak intercity train station in Gulfport, Mississippi, United States. Gulfport is a former union station that served the Louisville and Nashville Railroad and Gulf and Ship Island Railroad (which was succeeded by the Illinois Central Railroad).
In 1986, the depot was designated a Mississippi Landmark by the Mississippi Department of Archives and History. The building serves as the Gulfport Centennial Museum. It is also a contributing property of the Gulfport Harbor Square Commercial Historic District. Train service has been suspended since Hurricane Katrina struck Gulfport in 2005.