Ōtsu-juku (大津宿, Ōtsu-juku) was the last of the sixty-nine stations of the Nakasendō, as well as the last of the fifty-three stations of the Tōkaidō. It was 14 km (9 mi) from the previous post town, Kusatsu-juku, and was located in Ōmi Province. It is currently located in the present-day city of Ōtsu, Shiga Prefecture, Japan.
The road through Ōtsu-juku is flat and runs along the bank of Lake Biwa, passing the jōkamachi of Zeze Domain. Before entering Ōtsu-juku, the road made several double-bends intended to slow down any attacker in front of Zeze Castle. Ōtsu had been the capital of Japan briefly in the 7th century and was an important town due to its location on the outlet Lake Biwa via the Seta River, which becomes the "Uji River" is Kyoto and the "Yodo River" in Osaka. A famous ancient Chinese-style bridge crossed the river at this point. This bridge was much celebrated in literature and marked the edge of the capital region.
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