Phra Khanong (Thai: พระโขนง, pronounced [pʰráʔ kʰā.nǒːŋ]) is one of the 50 districts (Khet) of Bangkok, Thailand. Its neighbor, clockwise from north, are Suan Luang, Prawet, and Bang Na districts of Bangkok, Amphoe Phra Pradaeng of Samut Prakan Province (across Chao Phraya River), Khlong Toei and Watthana of Bangkok.
Phra Khanong was an amphoe of Nakhon Khuean Khan back in 1902. Nakhon Khuean Khan was renamed to Phra Pradaeng in 1914. In 1927 Phra Khanong was transferred from the then Phra Pradaeng province to Bangkok. It was once very big but it has since been split into several small districts. The districts Khlong Toei, Watthana, Suan Luang, Prawet and Bang Na were all once part of Phra Khanong. Khlong Toei (later split out Watthana) and Prawet (later separate out Suan Luang) districts were carved out of Phra Khanong in 1989. Bang Na was the last district to leave Phra Khanong in 1998.