Saint Thomas Aquinas Cathedral is the mother church of the Roman Catholic Diocese of Reno, Nevada, United States. It is located at 310 W. 2nd Street in Reno. It was built in 1908 as the rise in Reno's Catholic population warranted a larger church. The cathedral was nearly destroyed by a fire in 1909 and was restored the following year. The cathedral complex was listed on the National Register of Historic Places in 2022.

On May 21, 1906, Catholic officials purchased the Sol Levy home at the corner of Second and Chestnut (now Arlington) streets in Reno for $10,000 to be the site of St. Thomas Aquinas Cathedral. The cornerstone was laid in June 1906 and the cathedral was dedicated June 21, 1908. A fire on December 21, 1909, caused major damage, including the collapse of the ceiling, but it was salvaged and reopened in 1910. In 1931, Pope Pius XI appointed the first Bishop of Reno as Thomas Kiely Gorman DD. D. Sc. Hist. which established the Diocese of Reno. The church became known as the Cathedral and a bishop's chair was installed, that remains today. A renovation conducted in the 1950s added a wraparound mural that surrounds the altar. In 2010, an expansive retrofit was conducted to stabilize the foundation of the church.