Santa Teresa (Portuguese pronunciation: [ˈsɐ̃tɐ teˈɾezɐ]) is the name of a neighborhood in the city of Rio de Janeiro, Brazil. It is located on top of the Santa Teresa hill, by the centre of Rio, and is famous for its winding, narrow streets which are a favourite spot for artists and tourists.

The neighborhood originated around the Santa Teresa Convent, built in the 1750s on the Desterro hill. At the end of the 19th and early 20th century it was an upper class borough, as testified by its many opulent villas. Santa Teresa ceased being an upper-class neighbourhood long ago, but it has been revived as a fashionable hotspot. It is home to several artists and art studios and galleries. The offer of restaurants and bars is also varied.