The Church of Santi Domenico e Sisto (Saints Dominic and Sixtus) is one of the titular churches in Rome, Italy in the care of the Roman Catholic Order of Preachers, better known as the Dominicans. It is located at no. 1 Largo Angelicum on the Quirinal Hill on the campus of the Pontifical University of St. Thomas Aquinas (Angelicum), of which it is the University Church.
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