Palazzo Braschi [paˈlat.tso ˈbras.ki] is a large Neoclassical palace in Rome, Italy and is located between the Piazza Navona, the Campo de' Fiori, the Corso Vittorio Emanuele II and the Piazza di Pasquino. It presently houses the Museo di Roma, the "museum of Rome", covering the history of the city in the period from the Middle Ages through the nineteenth century.

It was built by the papal nephew Duke Luigi Braschi Onesti, to designs by Cosimo Morelli. The site was purchased in 1790 by Braschi, supported by funds from Pope Pius VI; Braschi demolished the 16th-century palace that Giuliano da Sangallo the Younger had built for Francesco Orsini in order to erect his own from the ground up. Construction was suspended in February 1798 during the Napoleonic occupation of the city, when the French temporarily took possession of it until 1802 and confiscated the recently acquired collection of antiquities it contained (though Braschi was reimbursed for them). In 1809, when Rome was declared an Imperial city by Napoleon, Duke Luigi moved into the palace and was declared mayor.