Sale is a small town in Greater Manchester, five miles southwest of city centre. It was a market town in Cheshire which became industrial in the 18th century, and in 1974 became part of the Borough of Trafford, along with nearby Altrincham and Stretford. It's nowadays a commuter town for Manchester.
From Manchester Airport you can take any train to Piccadilly then change, though it's a big station with a long walk between some platforms. But two trains an hour (for Blackpool and for Liverpool) run via Manchester Deansgate on the tram route: the fare is the same but it might save 20 min. You could even take the tram all the way from the airport, a slow journey for not much cheaper.