South San Francisco is a city in San Mateo County, California, United States, located on the San Francisco Peninsula in the San Francisco Bay Area. The city is colloquially known as "South City". The population was 63,632 at the 2010 census.
Prior to European exploration, the northern San Francisco peninsula was inhabited by the Ramaytush, a linguistic sub-group of the Ohlone people. Their village of Urebure on San Bruno Creek was visited by the Gaspar de Portolà expedition in 1769; remains of long-term (5,000+ years) inhabitancy and seasonal encampments have been examined at the Siplichiquin and Buckeye shell-mounds on San Bruno Mountain. Charcoal-sampling indicates these sites may have been actively occupied early in the Spanish colonial period (late 1700s). The delta of Colma Creek was formerly an important habitat for the waterfowl known to be hunted by the Ramaytush in historic times, and archaeologic sites have been recorded near the creek. The City plan also recognizes the existing remains of a village (CA-SMA-299) along El Camino Real.
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