Wilkes-Barre ( WILKS-bair or -⁠bair-ee) is a city in and the county seat of Luzerne County, Pennsylvania, United States. Located at the center of the Wyoming Valley in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is the second-largest city, after Scranton, in the Scranton–Wilkes-Barre–Hazleton, PA Metropolitan Statistical Area, which had a population of 567,559 as of the 2020 census, making it the fifth-largest metropolitan area in Pennsylvania (after the Delaware Valley, Greater Pittsburgh, the Lehigh Valley, and Greater Harrisburg).

Wilkes-Barre and the surrounding Wyoming Valley are framed by the Pocono Mountains to the east, the Endless Mountains to the north and west, and the Lehigh Valley to the south. The Susquehanna River flows through the center of the valley and defines the northwestern border of the city.

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