Yasothon (ยโสธร) is a town and province in the Isaan region of Thailand.
Use Hwy 1 (Pahol Yothin Rd) and turn right at Saraburi onto Hwy 2 (Mitraphap Rd). Keep going via Korat to Phimai, Nong Song Hong, and Ban Phai of Khon Kaen. Get onto Hwy 23, travel via Boraue, Maha Sarakham, Roi Et, Thawatburi, and Seraphume to Yasothon. This route is 531 km and it takes 7 hours.